With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-31-7,1-Ethylpiperazine-2,3-dione,as a common compound, the synthetic route is as follows.
59702-31-7, 1) taking N-ethyldioxypiperazine 14.2 g (0.10 mol),Transfer to a 500 mL three-necked flask, stir, and add 200 mL of dichloromethane.Cool down to -25 to -20 C, add 16.3 g (0.15 mol) TMCS,Control temperature -25 ~ -20 C, add 11.9g (0.15mol) pyridine,Adding 0.018 g of DMAP, adding 11.9 g (0.04 mol) of triphosgene in batches at a temperature of -25 to -20 C, and maintaining the reaction for 30-60 minutes;After the reaction was completed, suction filtration, washing with 30 mL of dichloromethane and distillation to dryness under reduced pressure.Add 100 mL of n-hexane to crystallize and filter by suction.Drying gave 19.3 g of N-ethylbisoxypiperazine chloride in a yield of 94.3%.
59702-31-7 1-Ethylpiperazine-2,3-dione 108812, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Qilu Tianhe Huishi (Leling) Pharmaceutical Co., Ltd.; Qilu Tianhe Huishi Pharmaceutical Co., Ltd.; Sun Zhengjun; Fan Changying; Sun Yue; Li Yong; (7 pag.)CN109734725; (2019); A;,
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