With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.
76003-29-7, A mixture of 2,5-dibromopyridine (1.0 g, 4.21 mmol), pyrrolidin-2-one (2.54 g, 12.7 mmol),K2C03 (1.16 g, 8.42 mmol) , Cul (40 mg , 0.21 mmol), Ni Ni ,N2,N2-tetramethylethane-1,2-diamine (92mg 0.63 mmol) and dioxane (10 mL) was stirred at 110C for 12 h. The mixture was added water (30 mL), extracted with EA(20 mL x 3), the organic layers were washed with water (25 mL x 3) and brine (20 mL x 3), dried over Na2SO4, concentrated and purified by flash chromatography (silica gel, 40 g, PE/EA = 100/i to2/1) to give the title compound (750 mg, 50%) as a gray solid. LC-MS: [M+H] = 356.1.
The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; CHAN, Ho Man; FU, Xingnian; GU, Xiang-Ju Justin; HUANG, Ying; LI, Ling; MI, Yuan; QI, Wei; SENDZIK, Martin; SUN, Yongfeng; WANG, Long; YU, Zhengtian; ZHANG, Hailong; ZHANG, Ji Yue (Jeff); ZHANG, Man; ZHANG, Qiong; ZHAO, Kehao; (148 pag.)WO2017/221100; (2017); A1;,
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