With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.
General procedure: An aqueous solution of sodium bicarbonate (0.57g, 6.78mmol) (20mL) was stirred at r.t. for 10min, and then compound 5a (0.50g, 2.26mmol) in dichloromethane (10mL) was added under ice-cooling. Thiophosgene (0.39g, 3.39mmol) in dichloromethane solution (5mL) was added dropwise for 0.5h. Reaction was stirred under ice-cooling for 6h. The aqueous phase was extracted with dichloromethane (20mL¡Á3). The combined organic phase was washed twice with saturated brine (20mL¡Á2) and dried over anhydrous MgSO4. After filtration, the solvent of filtrate was removed in vacuo, and the residue was purified by silica gel column chromatography (DCM : MeOH=100 : 1) to afford compound 6a as a pale-yellow solid; Yield: 63%, 55121-99-8
The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
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