With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55083-85-7,1-(4-Chlorophenyl)piperazin-2-one,as a common compound, the synthetic route is as follows.,55083-85-7
4-Methoxy-3-(pyridin-2-ylethynyl)benzoic acid (51 mg, 0.2 mmol), 1-(4- chlorophenyl)piperazin-2-one (74 mg, 0.3 mmol), and triethylamine (105 uL, 0.75 mmol) were dissolved in 3 ml. of CH2CI2 and treated with HOBt (34 mg, 0.25 mmol) and EDC (48 mg, 0.25 mmol). The reaction was stirred at room temperature overnight and directly purified by flash chromatography on silica gel (CH2CI2/Et0Ac) to yield 85 mg (95%) of the product as a white solid.
The synthetic route of 55083-85-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; WYETH; WO2009/143404; (2009); A1;,
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