With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.
General procedure: A mixture of 5a(210 mg, 0.690 mmol) and MsOH (0.13 mL, 2.00 mmol) in EtOH (3 mL) was stirred at room temperature for 15 min. To this mixture was added 13a (170 mg, 0.543 mmol), and the reaction mixture was stirred at 100C for 2 h. After the mixture was cooled to room temperature, water and saturated aqueous NaHCO3 solution were added. The resulting slurry was extracted with CHCl3, and the organic layer was dried overNa2SO4, then concentrated in vacuo. The residue was purifiedby silica gel column chromatography (CHCl3/MeOH/28%aqueous NH3=50 : 1 : 0.1 to 30 : 1 : 0.1) to give 14a (180 mg,57%)., 122833-04-9
122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Iikubo, Kazuhiko; Kondoh, Yutaka; Shimada, Itsuro; Matsuya, Takahiro; Mori, Kenichi; Ueno, Yoko; Okada, Minoru; Chemical and Pharmaceutical Bulletin; vol. 66; 3; (2018); p. 251 – 262;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics