With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373608-48-1,tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 4-(4-chloro-1,6-naphthyridin-2-yl)-N,N-diethylbenzamide (300 mg, 0.88 mmol) in DMF (5 mL) were added tert-butyl 4-(3-aminopropyl)piperazine-1-carboxylate (321 mg, 1.32 mmol) and K2C03 (240 mg, 1.76 mmol). After stirred at 100C overnight, the reaction mixture was quenched with water (5 mL), and extracted with DCM (10 mL x 3). The organic layer was washed with water (10 mL x 3) and brine (10 mL), dried over Na2SO4, concentrated and purified by prep-HPLC to afford tert-butyl 4-(3 -((2-(4-(diethylcarbamoyl)phenyl)- 1 ,6-naphthyridin-4-yl)amino)propyl)piperazine- 1- carboxylate (300 mg, 62%) as yellow solid. HPLC/UV purity: 100%; LC-MS (ESI): 547.2 (M + 1)., 373608-48-1
373608-48-1 tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate 17750945, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; PINKERTON, Anthony B.; ARDECKY, Robert J.; ZOU, Jiwen; (256 pag.)WO2018/204176; (2018); A1;,
Piperazine – Wikipedia
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