1030377-21-9, (S)-1-Boc-2-(Hydroxymethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A vial was charged with 5-amino-3,6-dichloro-l ,2,4-triazine (589.6 mg, 3.57 mmol), triethylamine (1.5 mL, 10.76 mmol), (S)-tert-butyl 2-(hydroxymethyl)piperazine-l- carboxylate (890 mg, 3.99 mmol) in dioxane (12 mL). The mixture was heated at 95 C for 1.5 h using microwave. The mixture was cooled to room temperature and transferred into a flask with dichloromethane, concentrated to remove the solvents. The residue was mixed with saturated potassium carbonate, extracted with dichloromethane (3 x 40 mL). The combined organic solution was dried over anhydrous sodium sulfate, concentrated. The residue was separated with flash column chromatography on silica gel using 1-5% methanol in dichloromethane to afford the product (955.7 mg) in 78%. NMR (500 MHz, Chloroform- d) delta 5.30 (s, 2H), 4.69 (br, 1H), 4.45 (d, J= 12.3 Hz, 1H), 4.21 (s, IH), 3.88 (s, 1H), 3.52 (s, I 1H), 3.42 (s, 1H), 3.13 (d, J = 14.2 Hz, lH), 3.02 (t, J = 12.0 Hz, 1H), 2.93 (s, 1H), 1.43 (s, 9H). MS for C3H21CIN6O3: 345.2 (MH+)., 1030377-21-9
The synthetic route of 1030377-21-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NEKTAR THERAPEUTICS (INDIA) PVT. LTD.; NEKTAR THERAPEUTICS; SHARMA, PANKAJ; KHATRI, VIJAY KUMAR; GU, XUYUAN; SONG, YUAN; SHEN, MICHAEL LIXIN; SAUTHIER, JENNIFER RIGGS; ANAND, NEEL K.; KOZLOWSKI, ANTONI; ODINECS, ALEKSANDRS; RILEY, TIMOTHY A.; REN, ZHONGXU; MU. YONGQI; SHEN, XIAOMING; YUAN. XUEJUN; AURRECOECHEA, NATALIA; O’MAHONY, DONOGH JOHN ROGER; WO2015/92819; (2015); A2;,
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