Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-71-6,tert-Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

57260-71-6, Step 1: To a solution containing compound 1 (3.9 g, 31 mmol) and Boc-piperazine (6.3 g, 34 mmol) in N-methyl-2-pyrrolidone (NMP) (30 ml) was added K2C03 (8.5 g, 62 mmol). The mixture was stirred overnight at 135 C. After completion of the reaction, the mixture was poured into ice water, and the precipitate was collected to afford the desired product as a yellow solid (6.4 g, 72%).

As the paragraph descriping shows that 57260-71-6 is playing an increasingly important role.

Reference£º
Patent; ACETYLON PHARMACEUTICALS, INC.; SHEARSTONE, Jeffrey, R.; JARPE, Matthew, B.; (152 pag.)WO2016/57779; (2016); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.,59702-07-7

A mixture of 8-bromo-1- (5-isopropyl-2,4-dimethoxybenzene) -5,6-dihydro-4H-benzo [f] [1,2,4] 4,3-a] azepine (100 mg, 0.23 mmol)1-methylpiperazin-2-one (51 mg, 0.45 mmol)(15 mg, 0.026 mmol), 4,5-dibenzophenylphosphine-9,9-dimethyloxacenene (15 mg, 0.026 mmol) and sodium tert-butoxide (48 mg , 0.50 mmol) was added to dry toluene (2 mL).Under nitrogen protection,Microwave heated to 100 ¡ã C,Reaction for 2 hours.The residue was purified by column chromatography (dichloromethane / methanol = 100: 0 to 90:10, v / v) to give 4- (1- (5-isopropyl-2,4-dimethoxy Benzo [f] [1,2,4] triazolo [4,3-a] azepin-8-yl) -1-methylpiperazine- 2-on4-(1-(5-isopropyl-2,4-dimethoxyphenyl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a]azepine-8-yl)-1-methylpiperazin-2-onee(80 mg) in 74percent yield.

The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Hansoh BioMedical Co., Ltd.; Zhao, Zhiming; Deng, Xiangjun; Huang, Zhiqiang; Yu, Hongping; Xu, Yaocahng; Pan, Zhongzong; Bao, Rudi; (62 pag.)CN106349241; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.132710-90-8,1-Boc-4-(3-hydroxypropyl)piperazine,as a common compound, the synthetic route is as follows.

[0974] A second intermediate compound, 4-[3-(7-Benzyloxy-[1,8]naphthyridin-2-yloxy)-propyl]-piperazine-1-carboxylic acid tert-butyl ester, was produced as follows: A 5 L 4-necked flask, equipped with a mechanical stirrer, thermometer, nitrogen inlet and an addition funnel is charged with a solution of 4-(3-hydroxy-propyl)-piperazine-1-carboxylic acid tert-butyl ester, (129 g, 0.528 mol) in anhydrous THF (1.6 L) and cooled to -40 C. To this potassium tert-butoxide solution (580 mL, 1M in THF, 0.58 mol) is added drop-wise during 1 h, and stirred further for 30 min. 2-Benzyloxy-7-chloro-[1,8]naphthyridine (130 g, 0.48 mol) is added to the reaction mixture in portions at -40 C. during 1 h. The reaction is stirred for 4 h to bring to 0 C., then quenched with saturated ammonium chloride solution (1.5 L) and extracted with ethyl acetate (2 L and 1 L). The combined organic extracts are washed with brine (1 L), dried over anhydrous sodium sulfate and concentrated to afford the crude as a dark brown thick paste. The crude is purified by silica gel chromatography using 20-25% ethyl acetate in hexanes for elution to give the second intermediate compound as a thick almost colorless thick paste (126 g, 49.8%).

132710-90-8, 132710-90-8 1-Boc-4-(3-hydroxypropyl)piperazine 16217800, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; Clark, Jerry D.; Davis, Jamie M.; Favor, David; Fay, Lorraine K.; Franklin, Lloyd; Henegar, Kevin E.; Johnson, Douglas S.; Nichelson, Brian J.; Ou, Ligong; Repine, Joseph Thomas; Walters, Michael A.; White, Andrew David; Zhu, Zhijian; US2005/43309; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

c 1-(4-Acetaminophenyl)-4-tert-butyloxycarbonylpiperazine 2.8 g (0.01 mol) of 1-(4-aminophenyl)-4-tert-butyloxycarbonylpiperazine and 0.78 g=0.7 ml (0.01 mol) of acetyl chloride are dissolved in 50 ml of dry dimethylformamide, 1.3 g=1.8 ml (0.013 mol) of triethylamine are added dropwise with stirring and at room temperature and the mixture is stirred further overnight. It is then concentrated to dryness in vacuo and the residue is partitioned between ethyl acetate and 1N hydrochloric acid. The combined organic extracts are washed with saturated sodium hydrogen carbonate solution, dried and concentrated to dryness in vacuo. Yield: 2.0 g (62.0% of theory), Melting point: 143 C. Rf: 0.49 (silica gel; methylene chloride/methanol=9:1)

170911-92-9, The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Karl Thomae; US5994356; (1999); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

122833-04-9, Step 3: 1-(3-methoxyl-4-bromophenyl)-4-methylpiperazine 1-(3-Methoxyl-4-aminophenyl)-4-methylpiperazine (16.6 g, 75 mmol) and CuBr (21.5 g, 0.15 mol) were added into tetrahydrofuran (200 mL), and then amyl nitrite (17.6 g, 0.15 mol) was added dropwise under stirring. The resultant was stirred at room temperature for 1 hour and refluxed for 3 hours. After the resultant was cooled, it was filtered, and the filtrate was concentrated and isolated by silica gel column chromatography (petroleum ether: ethyl acetate = 1: 1) to give 1-(3-methoxyl-4-bromophenyl)-4-methylpiperazine (5.98 g, 28% yield). MS m/z [ESI]: 285.1 [M+1].

The synthetic route of 122833-04-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chia Tai Tianqing Pharmaceutical Group Co.,Ltd; Centaurus BioPharma Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; XIAO, Dengming; XU, Xinhe; LIU, Xijie; HU, Yuandong; YU, Honghao; LIU, Zhihua; PENG, Yong; SUN, Yinghui; LUO, Hong; KONG, Fansheng; HAN, Yongxin; SUN, Jian; EP2952510; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compound 1and analogues (6a-m) were obtainedby reaction of 1eq of 2-(((6-bromonaphthalen-2-yl)oxy)methyl)oxirane (intermediate 3) with the appropriate piperazinederivative (1.2eq) in EtOH (10 ml) at reflux for 5 to 8h. After concentrationunder reduced pressure of reaction mixture, the purified compounds wereobtained after purification by column chromatography using PE: EA (1:2) orrecrystallization in EtOAc., 21043-40-3

The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cherfaoui, Bahidja; Guo, Tian-Kun; Sun, Hao-Peng; Cheng, Wei-Lin; Liu, Fang; Jiang, Fen; Xu, Xiao-Li; You, Qi-Dong; Bioorganic and Medicinal Chemistry; vol. 24; 11; (2016); p. 2423 – 2432;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

j00268j 8-Cyclopropyl-6-(4-fluorophenyl)imidazo[ 1 ,2-b]pyridazine-2-carboxylic acid (80 mg, 0.27 mmol) was dissolved in DMF (3.4 mL) and DIPEA (121.7 mg, 164 tL, 0.94 mmol) followed by tert-butyl 3,3-dimethylpiperazine-1-carboxylate (69.20 mg, 0.3229 mmol) were successively added at r. t. After 2 mi HATU (153.5 mg, 0.40 mmol) was added and the reaction mixture was stirred at r.t. ON. Water was added and the reaction mixture and the mixture was extracted with EtOAc. The resulting organic phase was washed twice with a 1:1 mixture of water and brine, dried over anhydrous Mg504, filtered and evaporated under reduced pressure. The resulting crude product was used as such in the next reaction. LC-MS:mlz = 494.26 (M+Hj.

259808-67-8, 259808-67-8 1-Boc-3,3-Dimethylpiperazine 22710387, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; FARMER, Luc J.; FOURNIER, Pierre-Andre; LESSARD, Stephanie; LIU, Bingcan; ST-ONGE, Miguel; STURINO, Claudio; SZYCHOWSKI, Janek; YANNOPOULOS, Constantin; WO2015/48245; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

154590-35-9, tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

154590-35-9, Step 1: To the product of Preparation 13, Step 3 (2.50 g, 8.5 mmol) and bis(2-chloroethyl ether (1.33 g, 9.3 mmol) in EtOH (20 ml) add KOH (0.95 g, ?14 mmol) in water (15 ml). Heat at 95 C. 5 d, allow to cool, and partition with ether and water. Dry (MgSO4) and concentrate to obtain the morpholine as a yellow solid

As the paragraph descriping shows that 154590-35-9 is playing an increasingly important role.

Reference£º
Patent; Schering Corporation; US2004/220194; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196811-66-2,tert-Butyl 4-carbamothioylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred solution of tert-butyl 4-carbamothioylpiperazine-1-carboxylate (synthesized according to Example 5, Step 1, 2 g, 13.75 mmol) in dioxane (20 mL), triethyl amine(1.7 mL, 12.24 mmol) and 1-bromo-3,3,3-trifluoro acetone (3.2 g, 16.5 mmol) were added and stirred at 90 C for 3 h. The completion of the reaction was monitored by TLC. The reaction mixture was quenched with water (10 mL) and extracted with ethyl acetate (2 x 25 mL). The organic layer was separated, dried over anhydrous Na2504, concentrated under vacuum and was used as such for next step. Yield: 75% (1.0 g,white solid). 1H NMR (300 MHz, DMSO-d6): 67.57 (s, IH), 3.42 (m, 8H), 1.40 (s, 9H). LCMS: (Method A) 338.0 (M+H), Rt. 5.37 mm, 99.0% (Max)., 196811-66-2

196811-66-2 tert-Butyl 4-carbamothioylpiperazine-1-carboxylate 12093220, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; TORONTO, Dawn, V.; CROWE, David, Malcolm; (150 pag.)WO2017/144637; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of tert-butyl 4-(2-amino-5-bromo-3-nitropyridin-4-yl)piperazine-1-carboxylate (250 mg, 0.62 mmol) in CH2Cl2 (2.5 mL) at 0¡ã C. was treated with TFA (2.5 mL) and stirred at 0¡ã C. for 1.5 h. After this time, the solvents were evaporated in vacuo and the excess TFA removed by azeotroping with toluene (3.x.10 mL). The residue was suspended in CHCl3 (3 mL) and pyridine (3 mL) and treated with benzenesulfonyl chloride (1.1 eq, 0.68 mmol, 0.09 mL), warmed to room temperature and stirred for 12 h. The solvents were removed in vacuo and the residue partition between water (5 mL) and EtOAc (5 mL). The aqueous layer was extracted with EtOAc (2.x.5 mL) and the combined organic extracts were dried (MgSO4) and concentrated in vacuo. Column chromatography (hexane-EtOAc, 1:1) gave the product (107 mg, 39percent for two steps) as a yellow solid; 1H-NMR (500 MHz, DMSO-d6) 3.09 (br s, 8H, 2.x. piperazine N(CH2)2), 7.08 (br s, 2H, NH2), 7.67-7.70 (m, 2H, phenyl H-3 H-5), 7.74-7.78 (m, 3H, phenyl H-2, H-4 H-6), 8.16 (s, 1H, pyridine H-6);LC (Method A)-MS (ESI, m/z): Rt=7.04 min-442, 444 [(M+H)+, Br isotopic pattern)., 192130-34-0

The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE INSTITUTE OF CANCER RESEARCH; US2009/247507; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics