With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.,115761-79-0
Take 50mL single-mouthed flask, was successively added 2-(1-(hydroxymethyl)cyclopropyl)methoxy-5-(methylsulfonyl)benzoic acid (150mg, 0.50mmol), 1-(2,4-difluorophenyl)piperazine (120mg, 0.60mmol), HATU (285mg, 0.75mmol), TEA (0.25mL, 1.5mmol), DMF (10mL), the reaction at room temperature overnight, saturated sodium chloride (20 mL), and extracted with ethyl acetate (20mL * 3). The organic phase was dried over anhydrous sodium sulfate and concentrated to dryness to give crude, the crude product was purified by preparative plate 130mg, yield: 55%.
The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shanghai Hansoh BioMedical Co., Ltd.; Jiangsu Stockhausen Pharmaceutical Group Co., Ltd.; Liao, Jianchun; Yu, Hongping; Xu, Yaochang; Chen, Jianghua; Zhang, Shaobao; Xiu, Wenhua; Liu, Zhaomin; (48 pag.)CN105712952; (2016); A;,
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