With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.474711-89-2,Piperazine-1-carboxamide hydrochloride,as a common compound, the synthetic route is as follows.,474711-89-2
The compound (S) -5- (1 – ((tert-butoxycarbonyl) amino) ethyl) -2- (3- (cyclopropylmethoxy) -4-(difluoromethoxy) phenyl ) -oxazole-4-carboxylic Acid (300mg, 0.64mmol), piperazine-1-carboxamidecompound hydrochloride (127mg, 0.77mmol), 1- ethyl-3- (3-dimethylaminopropyl) carbon Carbodiimidehydrochloride (250mg, 1.3mmol) and N- hydroxy-7-aza-benzotriazole (130mg, 0.96mmol) was dissolved indichloromethane (15 mL), at 0 C conditions, to this solution was added dropwise N, Ndiisopropylethylamine(0.44mL, 2.56mmol), stirred at room temperature 5H, water (10mL ¡Á 3) washing theorganic phase was dried over anhydrous Na 2 SO 4, the solvent was removed concentrate was subjected tocolumn chromatography (eluent: DCM / MeOH (V / v) = 40/1), to give 250mg white solid, yield: 70%.
As the paragraph descriping shows that 474711-89-2 is playing an increasingly important role.
Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
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