With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
59702-07-7, A mixture of 4,5-dibromo-2-(4-fluorobenzyl)pyridazin-3(2H)-one (0.8 g, 2.21 mmol), 1- methylpiperazin-2-one (0.33,2.87 mmol; see Example 7, Step 3), and diisopropylethyl-amine (0.34 g, 3.32 mmol) in absolute ethanol (3 mL) was heated in a sealed tube in an oil bath at 100 ¡ãC overnight. The mixture was concentrated under vacuum. The residue was partitioned between ethyl acetate and brine. The organic extract was dried over sodium sulfate, filtered, and concentrated under vacuum. The residue was subjected to column chromatography on silica gel eluted with hexanes and ethyl acetate gradient to give titled material. 1H NMR (400 MHz, CDCI3) No. 7.50 (s, 1H), 7.44 (dd, J = 8.6,5.4 Hz, 2H), 7.00 (t, J = 8.7 Hz, 2H), 5.27 (s, 2H), 4.00 (s, 2H), 3.71 (t, J = 5.6 Hz, 2H), 3.51 (t, J = 5.6 Hz, 2H), 3.03 (s, 3H). ES MS M+l = 395.2, 397.2
59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK & CO., INC.; WO2005/110414; (2005); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics