With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.,59702-07-7
Preparation of compound 30a: 4-(6-(5-(5-(4-methoxybenzylamino)-l,3,4-thiadiazol- 2-yl)-l-tosyl-lH-indol-3-yl)pyridin-2-yl)-l-methylpiperidin-2-oneA glass microwave reaction vessel was charged with 5-(3-(6-fluoropyridin-2-yl)-l-tosyl- lH-indol-5-yl)-N-(4-methoxybenzyl)-l,3,4-thiadiazol-2-amine (300 mg, 0.512 mmol) and l-methylpiperazin-2-one (117 mg, 1.024 mmol) in NMP (5 mL) followed by Et3N (214\L, 1.537 mmol). The reaction was stirred and heated in an oil bath at 150 ¡ãC for 60 h, and the mixture was diluted with DCM and washed with H20, brine, dried, filtered and concentrated to give the crude product. MS (ESI, pos. ion) m/z: 680 (M+1).
The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AMGEN INC.; WANG, Hui-Ling; CEE, Victor, C.; HERBERICH, Bradley, J.; JACKSON, Claire, L., M.; LANMAN, Brian, Alan; NIXEY, Thomas; PETTUS, Liping, H.; REED, Anthony, B.; WU, Bin; WURZ, Ryan; TASKER, Andrew; WO2012/129338; (2012); A1;,
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