With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129799-08-2,1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.
Step 5: The preparation of 4-(3-Methyl-butyl)-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester: Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (6.0 g, 24.6 mmol) was treated with EtOH (100 mL), isovaleraldehyde (5.3 mL, 50 mmol), and 20% Pd/C (1.0 g), then shaken under an atmosphere of H2. The reaction was filtered and concentrated. The residue was chromatographed on silica gel eluding with 2:1 hexanes/EtOAC to give 7.0 g (90%) of the desired product as an oil. MS: 316 (M+1 for C16H30N2O4); colorless liquid; TLC: SiO2, Rf0.8 (50% hexanes/EtOAc);, 129799-08-2
As the paragraph descriping shows that 129799-08-2 is playing an increasingly important role.
Reference£º
Patent; Warner-Lambert; US6251919; (2001); B1;,
Piperazine – Wikipedia
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