With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161357-89-7,1-(Methylsulfonyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.
A suspension of (3R,4S)-1-benzyl-4-(4-bromophenyl)-N,N-dimethylpyrrolidin-3-amine (3.24 g, 9.02 mmol), 1-(methylsulfonyl)piperazine hydrochloride (2.172 g, 10.82 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.826 g, 0.902 mmol), 2-(dicyclohexylphosphine)-2′,4′,6′-tri-isopropylbiphenyl (0.860 g, 1.803 mmol) and sodium tert-butoxide (2.167 g, 22.54 mmol) in dioxane (32.2 ml) in a 250 ml round bottom flask was taken through three vacuum/nitrogen-purge cycles and heated in a heating block under a condenser at 110C for 2 hours. The mixture was diluted with ethyl acetate and filtered through diatomaceous earth with ethyl acetate washes. The filtrate was washed with saturated sodium bicarbonate (20 ml), dried with magnesium sulfate, filtered, and concentrated. The residue was flash chromatographed (50 mm silica gel column; 6.5% methanol/dichloromethane w/0.1% ammonium hydroxide) to afford the title compound., 161357-89-7
The synthetic route of 161357-89-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Curtin, Michael L.; Pliushchev, Marina A.; Li, Huan-Qiu; Torrent, Maricel; Dietrich, Justin D.; Jakob, Clarissa G.; Zhu, Haizhong; Zhao, Hongyu; Wang, Ying; Ji, Zhiqin; Clark, Richard F.; Sarris, Kathy A.; Selvaraju, Sujatha; Shaw, Bailin; Algire, Mikkel A.; He, Yupeng; Richardson, Paul L.; Sweis, Ramzi F.; Sun, Chaohong; Chiang, Gary G.; Michaelides, Michael R.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 7; (2017); p. 1576 – 1583;,
Piperazine – Wikipedia
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