115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A reaction mixture of 8 (0.235 g, 1.0 mmol), l-(2,4-difluorophenyl)piperazine (0.208 g, 1.1 mmol), Pd(OAc)2 (28.8 mg, 0.13 mmol), BINAP (0.135 g, 0.22 mmol), and CS2CO3 (0.427 g, 1.3 mol) in dry toluene (5 mL) was stirred at 50 C for 48 h. After cooling, the palladium catalyst was removed by filtration through Celite pad. The product mixture was diluted with ethyl acetate (50 mL) and washed with aqueous NaHCCte (10 mL x 2) and brine (10 mL x 2). The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo. The resulting product was purified by flash chromatography to yield 9 as a white solid (0.252 g, 0.72 mmol, 72%); Rf = 0.36 (20% ethyl acetate in hexane). NMR (400 MHz, CDCb) delta 7.83 (t, J = 8.8 Hz, 1H), 6.95 – 6.87 (m, 1H), 6.86 – 6.76 (m, 2H), 6.65 (dd, J = 9.0, 2.5 Hz, 1H), 6.54 (dd, J = 14.6, 2.5 Hz, 1H), 3.86 (s, 3H), 3.49 – 3.41 (m, 4H), 3.13 (dd, J = 6.2, 4.0 Hz, 4H). 13C NMR (101 MHz, CDCb) delta 165.09, 164.93, 164.89, 162.53, 159.53, 159.42, 157.1 1, 157.06, 157.00, 156.95, 155.53, 155.42, 154.59, 154.47, 136.30, 136.26, 136.21, 136.17, 133.44, 133.41, 119.80, 1 19.76, 1 19.71, 119.67, 1 1 1.02, 1 10.99, 1 10.81, 1 10.78, 109.50, 109.48, 107.70, 107.60, 105.16, 104.92, 104.90, 104.66, 101.75, 101.48, 77.16, 51.84, 50.60, 50.57, 47.43. MS (ESI) m/z 351 [M+H]+., 115761-79-0
The synthetic route of 115761-79-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; ROUSH, William R.; CHOI, Jun Yong; PODUST, Larissa; WO2015/48306; (2015); A1;,
Piperazine – Wikipedia
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