With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.
B) 4-(4-Iodo-benzyl)-3-oxo-piperazine-l-carboxylic acid tert-butyl ester: Sodium hydride (1.30 g, 33.5 mmol) was added to a slurry of 3-oxo-piperazine-l- carboxylic acid tert-butyl ester (6.70 g, 33.4 mmol) from step A in 25 mL dry N,N- dimethylformamide and 90 mL dry tetrahydrofuran under argon atmosphere and cooled to O0C. The mixture was stirred at room temperature until a solution was obtained after 30 minutes. 4-Iodobenzyl bromide (9.90 g, 33.4 mmol), dissolved in 20 mL tetrahydrofuran, was added dropwise. The reaction was stirred for 1 hour to give a white slurry. Ethyl acetate and water was added. The organic phase was washed three times with water, once with brine, dried (sodium sulfate) and evaporated. The crude was purified on a silica column using dichloromethane / methanol (97 : 3) as eluent to give 12.2 g of the sub-title product (yield 87 %). 1H NMR (400 MHz, chloroform-d as solvent and internal reference) delta(ppm) 1.46 (s, 9H), 3.24 (m, 2H), 3.58 (t, 2H, J= 5.2 Hz), 4.14 (s, 2H), 4.54 (s, 2H), 7.01 (d, 2H, J= 8.3 Hz), 7.66 (d, 2H, J= 8.4 Hz)., 76003-29-7
As the paragraph descriping shows that 76003-29-7 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; WO2007/8144; (2007); A1;,
Piperazine – Wikipedia
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