With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
2.6 g of 3-oxetanone, 1.0 g of sodium cyanoborohydride and 0.16 ml of acetic acid are added to a solution of 2.0 g of benzyl piperazine-1-carboxylate in 20 ml of acetonitrile and then stirred for 16 hours at RT. The reaction mixture is diluted with water and filtered through a Chem Elut.(R). cartridge, eluting with DCM. The combined organic phases are dried over MgSO4 and the solvent is evaporated under vacuum. The residue is purified by preparative HPLC and 1.7 g of a white solid is obtained.
31166-44-6, The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SANOFI; US2012/277205; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics