Month: August 2020

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 39; Synthesis of provide 4-(5-(7-methoxy-6-(2-methoxyethoxy)cinnolin-4-yl)pyridin-2-y I)-I- methylpiperazin-2-one; [00304] In a microwave vial is placed 4-(6-fluoropyridin-3-yl)-6,7-dimethoxycinnoline(0.229 mmol) in 2 ml DMSO. l-Methylrhoiperazin-2-one hydrochloride (0.3626 g, 2.29 mmol) and potassium carbonate (0.147 ml, 2.40 mmol) is added and the temperature is brought to 90 0C to stir overnight. The reaction solution is allowed to cool to room temperature. The solution is moved to a separatory funnel and deionized water and ethyl acetate are added. The aqueous layer is extracted with ethyl acetate. The combined organic layers are washed with water, brine, dried with MgSO4, filtered, and concentrated. The crude product is adsorbed onto a plug of silica gel and chromatographed.

As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION; WO2007/100880; (2007); A1;,
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70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4-Nitrobenzyl bromide (46.3mmol) was dissolved in dichloromethane (100mL). The solution was added to the mixture of relative amine (47.0mmol) and triethylamine (70.3mmol) in dichloromethane (20ml). The reaction mixture was stirred at r. t. for 24 h and was extracted with dichloromethane (100ml¡Á3). After removal of the solvent, the residue was crystallized from ethanol, giving yellow powder. Compounds 1 and 2 were used for further reaction without purification. To a suspension of compounds 1-2 (36.2mmol) in 95% ethanol (100ml), 85% NH2NH2¡¤H2O (362mmol), 95% ethanol (100ml) and iron (III) oxide hydroxide (FeO(OH)/C, 2.0g) were added and heated to reflux. When TLC analysis showed complete conversion of the starting material, the reaction mixture was filtrate through Cellit and the filtrate was concentrated in vacuum. The crude product was purified by silica gel colum chromatography (DCM/MeOH) to yield the title compound (3 and 4) as white solid. The mixture of compound 4 (1eq, 18.5mmol), 4-Nitro-1H-pyrazole-3-acid (1.1equiv, 20.4mmol), EDC (1.2equiv, 22.2mmol), HOBT (1.2equiv, 22.2mmol) in DMF (50ml) was stirred for 24h. The ice water (100ml) was added to the reaction mixture. A large amount of yellow solid precipitation (compound 8) was acquired. Compound 8 was used without further purification. Compounds 8 was reduced by the same process as compound 4, and then the resulting compound 12 was purified by column chromatography on silica gel, eluted with the appropriate solvent.

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Zhi, Yanle; Li, Baoquan; Yao, Chao; Li, Hongmei; Chen, Puzhou; Bao, Jiyin; Qin, Tianren; Wang, Yue; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 303 – 315;,
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5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1 mole of 1-ethyl piperazine was dissolved in acetone and to it 3 moles of potassium carbonate was added with constant stirring. After 30 min, 1.5 mole of 1-bromo-3-chloropropane was added in drop wise manner and stirred for 12 h at RT. Later, solvent was evaporated from the reaction mixture and transferred to separating funnel having water and ethyl acetate. Organic layer was collected and evaporated to get 1-(3-chloropropyl)-4-ethylpiperazine asoily liquid. Yield 85%, IR (KBr, cm-1), 2954-2858 (Aliphatic CH str), 1350-1365 (-CN str); 1H NMR (400 MHz, Chloroform-d) delta 3.54 (t, J = 4.0 Hz, 2H), 3.16 – 3.06 (m,2H), 3.10 – 2.99 (m, 2H), 2.63 – 2.54 (m, 8H), 1.94 (tt, J =6.3, 4.0 Hz, 2H), 1.08 – 1.01 (m, 3H).

As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Article; Singh, Mahaveer; Jadhav, Hemant R.; Kumar, Amit; Letters in drug design and discovery; vol. 15; 8; (2018); p. 866 – 874;,
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109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the ionic liquid [TPA][Pro] (1 mL) was added amine (1-14; Table-1) (1 mmol) and di-tert-butyl dicarbonate (1.2 mmol). The reaction was stirred at room temperature for an appropriate time (Table-1). After completion of the reaction as monitored by TLC, water was added to the reaction mixture and the product was extracted into ethyl acetate (3 ¡Á 20 mL). The combined organic layer was washed with brine solution and concentrated under reduced pressure to give crude product, which was purified over silica gel column to afford corresponding N-tert-butylcarbamate. The ionic liquid [TPA][Pro] in aqueous solution was recovered by removing water under reduced pressure and dried. The recovered ionic liquid was reused for five times without loss of its activity. Finally, all the compounds confirmed by their m.p.?s, IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis wherever needed.

109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Vijaya Durga; Rambabu; Srinivasa Reddy; Hari Babu; Asian Journal of Chemistry; vol. 29; 6; (2017); p. 1313 – 1316;,
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115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(3-(7-Chloro-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)-4-methylphenyl)-3-(2-methoxyphenyl)urea (80 mg, 0.17 mmol) was dissolved in 2-butanol (0.85 mL). 4-(4-Ethylpiperazin-1-yl)aniline (38 mg, 0.19 mmol) and potassium carbonate (70.5 mg, 0.51 mmol) were added, the reaction vessel was transferred into an oil bath heated to 110 C., and Pd2(dba)3 (31 mg, 0.03 mmol) and Xphos (16.2 mg, 0.03 mmol) were added and stirred for 90 minutes. Then, when the reaction was completed, the reaction mixture was filtered using a celite pad and concentrated. The residue was purified by MPLC to obtain the desired compound (73.2 mg, 66.8%) as a white solid. Based on the method of Representative Synthesis Example 2, the compounds represented by Compound Nos. 11 to 18 were synthesized.

The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; SIM, Tae Bo; HUR, Woo Young; YOON, Ho Jong; SONG, Chi Man; JU, Eun Hye; CHO, Han na; CHOI, Hwan Geun; (17 pag.)US2018/65970; (2018); A1;,
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192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: One pot method was adopted for synthesis of 2a-k. Firstly, in a50 ml round-bottom flask, appropriate primary amine 1a-k(3.125 mmol), triethylamine (6.25 mmol) and CS2 (6.25 mmol) weredissolved in ethanol (15 mL). The reaction mixture was stirred for3 h at room temperature. Upon completion of the reaction, di-tertbutyldecarbonate (8.5 mmol), dissolved in absolute ethanol, wasadded followed by the immediate addition of a catalytic amount of4-dimethylaminopyridine (0.425 mmol). After the reaction mixturewas kept for further 30 min at room temperature, the solvent wasdistilled off under reduced pressure, and the residue was purifiedby column chromatography (petroleum ether/ethyl acetate= 4:1)to afford the corresponding 2a-k in 48-66% yield.

192130-34-0 tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate 1514400, apiperazines compound, is more and more widely used in various.

Reference£º
Article; He, Zhangxu; Qiao, Hui; Yang, Feifei; Zhou, Wenjuan; Gong, Yunpeng; Zhang, Xinhui; Wang, Haojie; Zhao, Bing; Ma, Liying; Liu, Hong-min; Zhao, Wen; European Journal of Medicinal Chemistry; vol. 184; (2019);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.259808-67-8,1-Boc-3,3-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

7-tert-butyl-5-(4,4-difluorocyclohexyl)furo[3,2-b]pyridine-2-carboxylic acid (910 mg, 2.697 mmol) and tert-butyl 3,3-dimethylpiperazine-1-carboxylate (578.0 mg, 2.697 mmol) was dissolved in DMF (3.3 mL). HATU (1.33 g, 3.51 mmol) and DIPEA (1.64 mL, 9.44 mmol) were successively added at RT. The reaction mixture was stirred overnight. EtOAc along with water were added. The phases were separated, and concentrated in vacuo to afford the title compound (950 mg, 66%). ESI-MS m/z calc. 533.3065, found 534.21. Rt: 2.48 min using Method C

As the paragraph descriping shows that 259808-67-8 is playing an increasingly important role.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; SAYEGH, Camil Elie; STURINO, Claudio; FOURNIER, Pierre-Andre; LACOSTE, Jean-Eric; DIETRICH, Evelyne; MARTEL, Julien; VALLEE, Frederic; (494 pag.)WO2016/154075; (2016); A1;,
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5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-ethylpiperazine (3.40g, 29.8mmol), 80 K2CO3 (4.10g, 29.6mmol), and 93 TBAI (0.42g, 1.2mmol) were added to a solution of 82 5-bromo-2-nitropyridine (4.00g, 19.7mmol) in 83 DMSO (40mL). The mixture was heated at 80C for 16h, and the reaction was poured into ice water, and extracted with DCM. The combined organic layers were washed with water, dried over anhydrous Na2SO4, concentrated under a vacuum, and purified by silica gel column chromatography (DCM/MeOH=100:1-10:1) to obtain 94 1-ethyl-4-(6-nitropyridin-3-yl)piperazine (3.59g; yield, 56%) as a yellow solid. Pd/C (0.10g) was added to the 1-ethyl-4-(6-nitropyridin-3-yl)piperazine (0.90g, 3.8mmol) in EA/MeOH (9 mL/9mL) solution. The mixture was degassed by H2, stirred at RT under a H2 atmosphere for 2h, and filtered and concentrated under a vacuum to obtain INT-2 (720.0mg; yield, 92%) as an off-white solid. ESI-MS: m/z 207.2 [M+H]+.

As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Article; Yin, Lei; Li, Heng; Liu, Wenjian; Yao, Zhenglin; Cheng, Zhenzhen; Zhang, Huabei; Zou, Hui; European Journal of Medicinal Chemistry; vol. 144; (2018); p. 1 – 28;,
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350684-49-0, tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The mixture of compound 10a-10e (3.24 mmol), compound 9(1.04 g, 3.4 mmol), Pd(OAc)2 (0.11 g, 0.5 mmol), Xantphos (0.28 g,0.5 mmol), and K3PO41.38 g, 6.48 mmolin DMF (8 mL) was heated 22 h at 125 C under argon followed by cooling to roomtemperature.The mixture was extracted with dichloromethane(20 mL x 3), the combined organic phase was washed with water(15mL x 2), dried over anhydrous Na2SO4 and concentrated toafford the crude product. The crude product was purified by columnchromatography to obtain compounds 11a-11e.

350684-49-0 tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate 2763355, apiperazines compound, is more and more widely used in various.

Reference£º
Article; Su, Yue; Li, Ridong; Ning, Xianling; Lin, Zhiqiang; Zhao, Xuyang; Zhou, Juntuo; Liu, Jia; Jin, Yan; Yin, Yuxin; European Journal of Medicinal Chemistry; vol. 177; (2019); p. 32 – 46;,
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192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Method B: Oxalyl chloride (2 M in CH2Cl2) was added dropwiseto an ice-cooled solution of 2 in dry CH2Cl2 under an argon atmosphere. After 1 h, the ice-bath was removed and the reaction batch was stirred overnight at ambient temperature in an atmosphere of Ar. Subsequently the solvent was evaporated in vacuo and the crude acyl chloride was dissolved in dry DMF and added dropwise to a stirred suspension of amine and K2CO3 in dry DMF at 0 ¡ãC. The stirring was continued for 1 h and then at ambient temperature overnight. After 20 h the suspension was filtered, the solvent evaporated, the residue taken up in water and extracted with CH2Cl2. The organic layer was washed with 5percent aqueous NaHCO3 and brine.Then it was dried over anhydrous sodium sulfate, filtered and the solvent was evaporated in vacuo yielding the raw quinoline-4-carboxamides 9?11, which were further purified by column chromatography.

The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hochegger, Patrick; Faist, Johanna; Seebacher, Werner; Saf, Robert; Maeser, Pascal; Kaiser, Marcel; Weis, Robert; Bioorganic and Medicinal Chemistry; vol. 25; 7; (2017); p. 2251 – 2259;,
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