With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.474711-89-2,Piperazine-1-carboxamide hydrochloride,as a common compound, the synthetic route is as follows.
Example 179 4-[6-(3-Methyl-1-trityl-1H-4-pyrazolyl)-4-quinolyl]-1-piperazine carboxamide A mixture of 150 mg 6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl trifluoromethane sulfonate obtained in Production Example 91, 83 mg 1-piperazinecarboxamide hydrochloride, 105 mg triethylamine and 10 ML anhydrous tetrahydrofuran was heated overnight under reflux.. Then, 5 ML dimethyl sulfoxide was added to the reaction solution, and the solution was stirred at 80C for 2 days.. The reaction solution was cooled to room temperature, then ethyl acetate, water and brine were added thereto, and the organic layer was separated, washed twice with water and then with brine, and dried over anhydrous magnesium sulfate.. The drying agent was evaporated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate), to give 96 mg of the title compound as a pale yellow amorphous.1H-NMR (CDCl3) delta: 2.55(s, 3H), 3.24(m, 4H), 3.68(m, 4H), 4.60(brs, 2H), 6.85(d, J=5.2Hz, 1H), 7.24(m, 7H), 7.33 (m, 8H), 7.53 (s, 1H), 7.65(dd, J=8.8,1.6Hz, 1H), 8.00(d, J=1.6Hz, 1H), 8.01(d, J=8.8Hz, 1H), 8.70(d, J=5.2Hz, 1H)
474711-89-2 Piperazine-1-carboxamide hydrochloride 2769700, apiperazines compound, is more and more widely used in various.
Reference£º
Patent; Eisai Co., Ltd.; EP1382603; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics