M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines was written by Budzik, Brian;Wang, Yonghui;Shi, Dongchuan;Wang, Feng;Xie, Haibo;Wan, Zehong;Zhu, Chongye;Foley, James J.;Nuthulaganti, Parvathi;Kallal, Lorena A.;Sarau, Henry M.;Morrow, Dwight M.;Moore, Michael L.;Rivero, Ralph A.;Palovich, Michael;Salmon, Michael;Belmonte, Kristen E.;Laine, Dramane I.;Jin, Jian. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Category: piperazines This article mentions the following:
Exploration of multiple regions of a bi-aryl amine template led to the identification of highly potent M3 muscarinic acetylcholine receptor antagonists such as (I) (pA2 = 11.0) possessing good sub-type selectivity for M3 over M2. The structure-activity relationships (SAR) and optimization of the bi-aryl amine series are described. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Category: piperazines).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics