Experimental studies on pharmacological protection of the brain against focal ischemia. 2. Effects of KB-2796 and nicardipine on focal brain ischemia in rats was written by Shiino, Akihiko. And the article was included in Archiv fuer Japanische Chirurgie in 1989.SDS of cas: 101477-54-7 This article mentions the following:
It has been proposed that calcium overload triggers neuronal cell damage in the acute stage of cerebral ischemia. In this study, the effects of calcium antagonists, KB-2796 and nicardipine, on neurol. deficits and size of the infarction were studied in the rat middle cerebral artery (MCA) occlusion model. Neurol. deficits were evaluated from 1 to 24 h after occlusion of the MCA, using the grading system of Bederson et al., 1986. At 24 h post-occlusion, the brain was removed, sliced coronally, and stained with triphenyltetrazolium chloride. Size of the infarction was measured by computerized image anal. system. KB-2796 (10 mg/kg) or nicardipine (1 mg/kg) was i.p. administered immediately after occlusion of the MCA. In the KB-2796-treated group, the neurol. deficits were much improved and the size of infarction was significantly smaller, but in the nicardipine-treated group improvement was modest and did not reach the level of statistical significance. The neurol. improvement was observed in the group where KB-2796 was given at 3 h postocclusion but the size of infarction was unchanged. The results indicate that the calcium antagonists could improve focal cerebral ischemia when administered in early stage of ischemia, and that such effect is more significant with KB-2796 probably because of its higher selectivity to the cerebral vessels. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7SDS of cas: 101477-54-7).
1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.SDS of cas: 101477-54-7
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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics